Correspondence: Mingjun Liu, and Xiaolin Zhang, professor, Changchun University of Chinese Medicine, 1035 Boshuo Road, Jingyue Economic Development Zone, Changchun City, Jilin Province 130117, China (e-mail: [emailprotected], [emailprotected]). AChinese researchclaimsthat ithas been used for viral infections for more than a decade, includingSevere Acute Respiratory Syndrome (SARS)in 20022003. Lianhua Qingwen (LHQW), a Chinese supplement approved by thePhilippine Food and Drug Administration (FDA) for mild Covid-19 symptoms,continues togain popularity and controversy. Epub 2021 Nov 2. Lianhua Qingwen combined with conventional drugs may be a promising therapy for treating common pneumonia and COVID-19 pneumonia. Bookshelf Shunya Zhu, Xiaoying Li, Yunling Wei, et al. National Class- A Varieties for Medical Insurance Drugs Cao B, Zhang D, Wang C. A trial of lopinavir-ritonavir in, [6]. Clinical observation shows that the total effective rate of traditional Chinese medicine is >90%.[15]. [28]. National Key New Product The proportion of severe patients admitted to covid-19 hospital is 15.7%, and the death rate of confirmed patients is 6.7%. For oral use after meals,4 capsules thrice daily or by medical ordor5 boxes for a treatment course. 2018;Beijing: Science and Technology Literature Press, 13271329. In addition, Manual retrieval of articles, conference papers, ongoing experiments, internal reports, among others, to supplement electronic retrieval. All tests are 2-tailed, and P < .05 is considered statistically significant. Pharmacology and clinical research of traditional Chinese medicine 2010;26:214. Avoid cigarettes, alcohol and keep from eating spicy, raw, cold or greasy food. [Drug Interactions]Interaction may appear if administered accompanied with other medicine, consult with doctors or pharmacists for details. ACTSmarket.com is the e-shop and distribution arm of ACTSmarket Ltd, Used for patterns of heat toxin assailing the lung in flu, manifested as fever, aversion to cold, muscle soreness, stuffy & runny nose, cough, headache, dry & sore throat, reddish tongue, yellow & greasy tongue coating. Writing review & editing: Xiaolin Zhang. Receive exclusive coupons and special offers directly to your email inbox. Already have Rappler+? In addition, we learned from the experience of Rhubarb in the treatise on Febrile Diseases in the treatment of epidemic diseases. 8.Three days without any remission,or symptems aggravated,appeared new serious symptems, should go to hospital. SHIJIAZHUANG YILING PHARMACEUTICAL CO., LTD. Lianhua Qingwen, a representative TCM patent product for the treatment of influenza. We will use the formal test for subgroup interactions in Review Manager 5.3. Patients with hypertension or heart disease should use with caution, patients with chronic disease such as diabetes, liver disease, kidney disease should take medicine under doctors direction. WebAs chemical analysis for quality control (QC) of traditional Chinese medicine (TCM) formula is difficult to guarantee the effectiveness, a bioassay method that combines QC with evaluation of therapeutic effects has been developed to assess the TCM quality. Patients diagnosed with COVID-19 of all ages and racial groups will be included. [3]. Guyatt GH, Oxman AD, Vist GE, et al. Lianhua Qingwen Capsules can significantly improve the total effective rate for COVID-19 patients, as well as shorten the hospital stay and treatment time, which is worth of promotion in the clinic. Therefore, it is essential to perform a systematic review and meta-analysis to assess the effect of Lianhua Qingwen combined with conventional antiviral Western Medicine in clinical treatment of COVID-19 or asymptomatic infection. Not suitable for long-term use. Placebo, routine western medicine therapy, and other therapeutic methods in the comparators (drugs, dose, frequency, duration); (5) Outcomes: the primary outcomes include total efficiency, primary symptoms, and Risk ratio (RR) was used to express the severe conversion rate and CT improvement rate absorption rate; mean difference (MD) was used to express the time of fever reduction in secondary indexes; Odds Ratio (OR) was used to express clinical efficiency and symptom disappearance rate. Lianhuaqingwen (LHQW) has anti-inflammatory and immune regulatory functions and may inhibit the airway inflammation that occurs during an acute exacerbation of COPD. Forsythiae Fructus, Lonicerae Japonicae Flos, Ephedrae Herba (processed with honey), Armeniacae Semen Amarum (stir-baked), Gypsum Fibrosum, Isatidis Radix, Dryopteridis Crassirhizomatis Rhizoma, Houttuyniae Herba, Pogostemonis Herba, Rhei Radix et Rhizoma, Rhodiolae Crenulatae Radix et Rhizoma, l-Menthol, Glycyrrhizae Radix et Rhizoma. STATA15.1 and RevMan5.3 software were used to analyze meta outcomes of different intervention measures for the treatment of new crown pneumonia and the control group (conventional antiviral western medicine treatment) clinical efficacy. Articles in Google Scholar by Xiaolin Zhang, MD, Other articles in this journal by Xiaolin Zhang, MD, Intermediate dose cytarabine improves survival and relapse-free rate compared with standard-dose cytarabine as post-remission treatment for acute myeloid leukemia: A retrospection study, Privacy Policy (Updated December 15, 2022). Philippines FDA approved LHQW for the treatment of mild Covid-19. Egger M, Davey Smith G, Schneider M, et al. 10. Though no specific drug has been developed so far, emerging agents have been confirmed effective or potentially beneficial to restrain it. Please abide by Rappler's commenting guidelines. WebLianhua Qingwen Dosage & Drug Information | MIMS Thailand Lianhua Qingwen(Forsythiae fructus 225 mg, Lonicerae japonicae flos 225 mg, Ephedrae herba Kupferschmidt K, Cohen J. Whether a fixed-effects or a random-effects model will be used depends on the results of I2 test for heterogeneity. 2020 Jul 24;99(30):e21404. As stated in the research paper published on "Scientific World Journal", Lianhua-Qingwen capsule (LQC) is a commonly used Chinese medical preparation to treat virus and especially played a very important role in the fight against severe acute respiratory syndrome (S-A-R-S) in 2002-2003 in China. Ephedra increases heartbeat and blood pressure. We will perform the sensitivity analysis to explore the effects of trial risk of bias on primary outcomes if possible. Therefore, the completeness of the evidence is not yet available. Please be informed that only the Your message has been successfully sent to your colleague. The full text of articles potentially suitable for the review will be obtained for further assessing eligibility based on the inclusion criteria or/and exclusion criteria. [19]. V03AX - Other therapeutic products ; Other products with therapeutic properties. [17]. A few patients have cough, expectoration, chest distress, dyspnea, muscle ache, diarrhea, and other symptoms. eCollection 2023. [16] SHI JIA ZHUANG YI LING PHARMACEUTICAL CO.,LTD. See this image and copyright information in PMC. In 2015, Diagnosis and Treatment Scheme for Cases Infected with Middle East Respiratory Syndrome (MERS) (2015), issued by the National Health and Family Planning Commission It is not necessary for ethical approval because this article is based on previously conducted studies and does not involve any new studies of human or animal subjects performed by any of the authors. Children, pregnant women, nursing mother, senile and infirm patients or those with week spleen should take medicine under doctors direction. It is based on the published clinical research literature at present stage. MJL will arbitrate any disagreement and ensure that no errors occur during the review. Buy two get one free promotion. Domingo said this version of the capsule was still unregistered to date, meaning the FDA could not guarantee its quality and safety. Chest radiographs. The general public is reminded that LHQW is only a traditional Chinese medicine and not a therapeutic drug for Covid-19. Nausea, diarrhea, vomiting, abdominal pain, dry mouth, rash, itching, dizziness. Preliminary study on the inhibitory effect of three prescriptions of traditional Chinese medicine on SARS related coronavirus in vitro [J]. It is compatible with Rhodiola to clear lung and remove blood stasis. Led by Iloilos most respected journalists, the Daily Guardian pledges to tell the Ilonggo story as seen through the various lenses of society so that every side may be told. cDepartment of lung diseases, the Third Clinical Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China. It is approved by HSA asan over-the-counter traditional Chinese medicine to treat influenza and colds. In 2019, Diagnosis and Treatment Scheme for Influenza (2019), issued by the National Health Commission The Authors. If meta-analysis is not applicable, we will conduct a systematic narrative synthesis providing information to summarize and explain the characteristics and findings of the included studies. Avoid alcohol and tobacco and spicy,cold, greasy food during taking this product. The COVID-19 may improve the clinical symptoms associated with fever, cough, and fatigue. COVID-19; Lianhua Qingwen; meta-analysis; protocol; systematic review. to maintaining your privacy and will not share your personal information without A trial of lopinavirritonavir in adults hospitalized with severe. In 2012, Prevention and Treatment Scheme of Traditional Chinese Medicine for Type B Influenza, issued by the State Administration of Traditional Chinese Medicine N Engl J Med 2020;382:92936. Novel coronavirus pneumonia is a new method for the treatment of new crown pneumonia. [31]. Contraindicated for the patients allergic to this product, be cautions about patients with allergic constitution. For the treatment of COVID-19, the main effects of Lianhua Qingwen are as follows: First, after taking the capsule, patients' symptoms improve quickly, two days earlier than the control group. Second, CT scan result also shows that patients recover faster than the control group. Third, the capsule can shorten fever time. BMC Complement Altern Med 2017;17:130. Chest radiographs of the patient. The patients receiving Lianhua Qingwen Capsule treatment were assigned to the observation group (n=33) and those given conventional therapy were included in In China, lianhua qingwen is recommended for treating thepneumonia. WhileDDB notes the FDAs approvalofLHQWas a traditional herbal product that may helprelievefever, muscle soreness, stuffy and runny nose associated with Covid-19, the DDBalsobelievesinpreventing diversion and unsafe use and abuseof this product withouthampering theaccess toit. Recently, the novel coronavirus pneumonia (COVID-19) epidemic has spread continuously and has been classified as class B infectious diseases (class a management). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. [1014] Data showed that novel coronavirus pneumonia was confirmed in China, and 74,187 people used Chinese medicine, accounting for 91.5%, of which 61,449 in Hubei Province used Chinese medicine, accounting for 90.6%. BackgroundLHQW's formulation is based on two ancient formulae from the Han and Qing dynasties - Maxing Shigan decoction and Yinqiao powder - following the SARS epidemic. Novel coronavirus pneumonia treatment plan (revised version 7) [EB/OL]. After determining how to combine different types of studies, NRIs use the method of inverse variance of random-effect model to evaluate and calculate the 95% CI of the effect value. The flow diagram of this systematic review is shown in Figure 1. [25]. Effect of Lianhuaqingwen Capsule on lung pathological injury and expression of inflammatory factors in mice induced by automobile exhaust [J]. The studies that do not fulfill the inclusion criteria will be excluded and listed with reasons for their exclusion. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology[32] will be used to assess the quality of the evidence and risk of bias with on-line GRADE (https://www.gradeworkinggroup.org/). Bethesda, MD 20894, Web Policies If you are using other drugs, please consult your doctor before using this product. The capsule was earlier developed in 2003 to treat the severe acute respiratory syndrome (SARS) and extracts the essence of 13 herbs. As a drug, ephedrine is a decongestant and bronchodilator. | 2023 ACTSmarket, capsules x 3 times a day ( after breakfast, lunch and dinner. [Description]Capsules, containing tan to brown granule and powder; odour, slightly aromatic; taste, slightly bitter. Highlight selected keywords in the article text. Follow her on Twitter via @sofiatomacruz. If substantial heterogeneity is identified, we will report it and explore possible causes using sensitivity analysis and subgroup analysis. 2.Its not appropriate to take nourishing chinese medicine wihte taking medicine. Lianhua Qingwen was developed by Shijiazhuang Yiling Pharmaceutical in 2003 as a treatment for severe acute respiratory syndrome (SARS) following the outbreak of the disease in 2002 and was listed by the National Health Commission of China in 2004 as a treatment for influenza and other respiratory disease. Please try after some time. Middle East respiratory syndrome case diagnosis and treatment program (2015 Edition) [J]. In accordance with the usage and dosage,the product should not be long term used. Lianhua Qingwen (LHQW) There are no comments yet. Upgrade to Rappler+ for exclusive content and unlimited access. may email you for journal alerts and information, but is committed 2011. [Storage]Preserve in tightly closed containers, stored in a cool and dry place (20). Consume daily after meal Available at: [30]. Asia's one-stop resource for medical news, clinical reference and education, Philippine Archipelago International Trading, Click to view Lianhua Qingwen detailed prescribing information. It has important clinical application value to treat patients with covid-19. Copyright 2023 MIMS Pte Ltd. All rights reserved. FREE SHIPPING within SG when you buy 4 boxes or more. Exclusion: studies using two or more Chinese herbal compound as intervention measures will be excluded. Medicine. [2] The main manifestations of the disease are fever, fatigue, and dry cough. Pharmacological experiments have indicated that a high dosage of Lianhua Qingwen alters the effectiveness of cyclooxygenase-2 in the arachidonic acid metabolic pathway and We aim to assess the efficacy and safety of Lianhua Qingwen combined with Conventional antiviral Western Medicine in Clinical treatment of COVID-19 or asymptomatic infection. Bias in. [15]. Here are links to the publications that published the results of the clinical trial :https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229744/https://en.prnasia.com/releases/global/tcm-lianhua-qingwen-shows-stable-in-vitro-antiviral-effect-on-the-delta-variant-expert-327965.shtmlIngredients & ContradicationsPlease refer to the pictures for more informationUSAGE FOR RESPIRATORY DISEASES SUCH AS FLUS AND COLDSProphylaxis: If you know you are going out, take LHQW the day before, the day of the outing and the day after the outing. Measuring inconsistency in meta-analyses. Hermetically sealed,keep in cool and dry places. Before the successful development of targeted vaccine, >4 million patients with covid-19 and asymptomatic infection around the world may also benefit from traditional Chinese medicine such as Lianhua Qingwen. Xiaoyan Liu. The Philippines Food and Drug Administration (FDA) has approved the traditional Chinese medicine (TCM) capsule Lianhua Qingwen widely used in China as 3.Patients with common cold due to wind-cold dont apply to the product. Avoid prolonged use. For the treatment, the main effects of Lianhua Qingwen Jiaonang capsule are as follows: First, Henan traditional Chinese medicine 2007;27:356. It is reported that the registration number of Lianhua Qingwen Capsules in the Philippines is THPR-50 and the product category is traditional herbal drugs. Data is temporarily unavailable. Patients with body temperature higher than 38.5 should see the doctor. [4] However, at present, there is no effective antiviral treatment drug confirmed for covid-19. Kunming: Kunming University of technology; 2015. New Chinese medicine and clinical pharmacology 2007;18:69. Chinese Journal of pharmacology and toxicology 2015;29:2137. PLoS One. Is there any notice for taking Lianhua Qingwen Capsules? Available at: [16]. Used in treatment of epidemic influenza and lung heat, symptom as fever or high fever, aversion to cold, muscular soreness, rhinostegnosis and nasal discharge, cough, headache, dry and sore throat, flushing tongue, or greasy fur of tongue. First case of 2019 novel coronavirus in the United States. Ephedra was banned from the Olympics and other sport events, even in the US military. The manuscript was drafted by XLZ and MJL. The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe. Product PackingEach box contains 24 capsules in blister packing. The two groups were compared in terms of clinical effects and main symptom (fever, cough and fatigue) disappearance rate. Abbreviations: BAs = comparison before and after the study, C0VID-19 = Corona Virus Disease 2019, ChiCTR = China Clinical Trial Registration Center, MERS = Middle East respiratory syndrome, NOS = Newcastle Ottawa scale, NTR = Netherlands National Trial Registration Center, PRISMA-P = Preferred Reporting Items for Systematic review and Meta-Analysis Protocols, RCTs = randomized controlled trials, RCSs = retrospective cohort study. Correct way is to take it orally, 3 capsules 1 time, 3 times a Experimental study of Lianhuaqingwen capsule against influenza A virus in vitro [J]. Please try again soon. Journal of Central South University for Nationalities: Natural Science Edition 2012;31:204. A: Before treatment; B: After treatment. Clinically, Lianhua Qingwen Capsule can be used in the treatment of cold, flu-induced bronchitis, pneumonia, COPD, interstitial pneumonia and other lung inflammation. Hai Guo, Jin Yang, Jiening Gong, et al. Click to view Lianhua Qingwen detailed prescribing information Overdosage View Lianhua Qingwen In the analysis, we will exclude lower-quality trials and repeat the meta-analyses to examine whether the quality of included studies influences the pooled results. Post code: 050035 Tel: 0086-311-85901643 Fax: 0086-311-85906730 Website: http://www.yiling.cn Any questions or problems, please do not hesitate to contact manufacturer. 94d329df351d7da8aefc2.shtml, https: //www.who.int/docs/default source/coronaviruse/situation-reports/20200325-sitrep-65-, https://www.jiyinzaixian.com/news/bNu5eb13ba6806e0, http://www.xinhuanet.com/politics/2020-03/24/c_1125757251.htm, http://www.nhc.gov.cn/yzygj/s7652m/202003/a31191442e29474b98bfed5579d5af95.shtml. Removes heat-toxin invasion of the lungs, including symptoms eg, fever, aversion to cold, muscle soreness, stuffy & runny nose. Meta-analysis on the effect of combining Lianhua Qingwen with Western medicine to treat coronavirus disease 2019. WebTo evaluate the efficacy and safety of Lianhua Qingwen capsule for influenza. The results will be cross-checked by the 2 reviewers, and any disagreements will be resolved by consensus, with any ongoing differences in opinion being arbitrated by a third reviewer (LMJ). For NRIs, evaluate its methodological quality with the Newcastle Ottawa scale (NOS). Go and see the doctor if the symptom is not alleviated 3 days after administration. [Administration and Dosage] Please enable scripts and reload this page. Third, the capsule can shorten fever & coughting time. Stage Food and Drug Administration Approval number:Z20040063.

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